Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8

Table 1 Percentage of medial and posterior articular cartilage degeneration in the tibial plateau in SAM

	% of medial cartilage surface degeneration^a	% of posterior cartilage surface degeneration
SAMP8
3 months	0.0% (0/6)	0.0% (0/6)
5 months	67.0% (4/6)	0.0% (0/6)
7 months	71.4% (5/7)	12.5% (1/8)
9 months	75.0% (6/8)	50.0% (4/8)
SAMR1
7 months	0.0% (0/6)	16.6% (1/6)
9 months	0.0% (0/8)	0.0% (0/8)
Treadmill
No-Ex	75.0% (6/8)	50.0% (4/8)
Ex	60.0% (6/10)	70.0% (7/10)

^a% of articular cartilage with 3-point difference between the medial and lateral plateau in the modified Mankin score. Knee joint on both sides were observed in each group (number of positive mice/numbers of observed mice). Animals of No-Ex group were equal to the 9-month-old SAMP8

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