Fig. 2From: Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitisNormalization of the microarray datasets (GSE79850) and differential gene expression analysis. The gene expression value data before and after normalization (A, B). C Principal component analysis (PCA) of the samples. Blue dots represented the PCA values of 8 healthy controls, and red blots represented 16 PBC patients. D Volcano plots of differentially expressed genes. Blue circles represented downregulated genes and red circles represented upregulated genes. The screening threshold was set as |Log2FC|> 1 and adjusted P-value < 0.05 (TXNIP: |Log2FC|= 2.033 P-adj = 0.006, ENTPD1: |Log2FC|= 2.149 P-adj = 0.002, CD44: |Log2FC|= 1.183 P-adj = 0.041, PDGFRB: |Log2FC|= 1.500 P-adj = 0.016). E Heatmap analysis of all differentially expressed genesBack to article page