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Table 1 The additional significantly associated genes identified through the ACAT approach

From: Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

OA

Symbol

P.ACAT

P.Bonferroni

Knee

AC005152.3

1.71E − 06

4.90E − 02

AL450226.2

1.76E − 07

5.04E − 03

COG8

1.30E − 07

3.74E − 03

CYB5B

3.14E − 07

8.98E − 03

HIC1

1.11E − 07

3.18E − 03

RP1-221C16.8

9.64E − 07

2.76E − 02

RP11-234K24.3

5.32E − 07

1.52E − 02

RP11-419C5.2

1.73E − 06

4.94E − 02

RP11-667K14.3

3.33E − 08

9.53E − 04

Hip

ALAS1

2.49E − 07

7.13E − 03

ALG1L11P

1.17E − 06

3.36E − 02

CLIP1

7.76E − 08

2.22E − 03

DIABLO

3.26E − 07

9.33E − 03

FAM86B3P

6.68E − 07

1.91E − 02

FAM90A10P

4.67E − 07

1.34E − 02

GLYCTK-AS1

1.01E − 06

2.89E − 02

ITIH3

1.18E − 08

3.39E − 04

MALAT1

8.25E − 07

2.36E − 02

NT5DC2

1.61E − 06

4.61E − 02

PBRM1

3.06E − 07

8.76E − 03

RP11-481A20.4

1.36E − 06

3.90E − 02

RP11-67K19.3

2.18E − 07

6.24E − 03

RP5-966M1.7

7.71E − 07

2.21E − 02

RPS7P11

5.52E − 07

1.58E − 02

SETD1B

8.67E − 08

2.48E − 03

SSSCA1-AS1

2.20E − 11

6.30E − 07

TNC

3.00E − 08

8.58E − 04

TNNC1

1.17E − 07

3.35E − 03

  1. OA Osteoarthritis, ACAT Aggregate Cauchy association test, P.ACAT P-value from ACAT analysis, P.Bonferroni Bonferroni-corrected P-value from ACAT analysis