Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Table 3 The top five significantly OA-associated chemicals identified through CGSEA analysis

OA	Chemical Name	MeSH® ID	NES	P-value
Knee	Acetaminophen	D000082	15.90	9.99E − 04
	Tetrachlorodibenzodioxin	D013749	37.22	9.99E − 04
	Aflatoxin B1	D016604	65.49	9.99E − 04
	Bisphenol A	C006780	6.69	2.00E − 03
	Cyclosporine	D016572	13.42	3.00E − 03
Hip	PCB 180	C410127	118.04	9.99E − 04
	Mercuric Chloride	D008627	76.38	9.99E − 04
	Atrazine	D001280	64.67	9.99E − 04
	Quercetin	D011794	61.42	9.99E − 04
	Genistein	D019833	56.48	9.99E − 04

OA Osteoarthritis, CGSEA Chemical-related gene set enrichment analysis, NES Normalized enrichment score

ISSN: 1478-6362