Fig. 4
Midnightblue module hub genes. A A total of 18 hub genes were identified within the midnightblue module, by selecting the top 10% of genes having the highest degree of intra-modular connectivity. These included 17 protein-coding genes (circles) and 1 lncRNA (diamond). All of the hub genes, except for TSPAN3, were significantly over-expressed (FC: 1.5–2.0) among the RAworsened women, compared to the RAimproved. B Data on protein–protein interactions (PPI) from the STRING database showed that most of the protein-coding hub genes (14 of 18) encoded proteins that interacted with one another functionally