Fig. 1

Susceptibility genes of primary Sjögren’s syndrome-associated pulmonary arterial hypertension identified by whole genome sequencing. Gene annotation: 1-10: BCR, FLG, CRB1, GIGYF2, ILDR1, ITK, LIPH, PRKRA, DYSF, ERCC2; 11-20: FMN2, GJB4, LAMC3, MLH1, MUTYH, NPHP4, SERPINB7, SLC26A4, SOHLH1, TNNI3; 21-30: ABCC6, ACADS, ACTN2, ADAMTS13, ADAMTS19, ADCY6, AGL, ALDH6A1, AQP5, ASPM; 31-40: ATIC, ATP11B, ATP1A3, ATP7A, BAP1, BBS7, BMP4, BRWD1, BSND, CBWD2; 41-50: CLIC6, CLPP, COL12A1, CRB2, CRYGS, CYP27A1, DDX41, DLL3, DMGDH, DNAAF1; 51-60: DNAH8, DNAJC2, DPYS, DUOXA2, ENO3, EPB41L4A, ERCC5, EYS, FAM214A, FANCE; 61-70: FBXL4, FIG4, FKRP, FMO3, FUT2, FZD10, GABRB3, GALK1, GCDH, GET4; 71-80: GJB2, HEXA, HEXB, IDH1, IFT122, INPPL1, INVS, KAT2B, KIAA0586, KIF1B; 81-90: KPNA4, KRT81, LARS2, LIPA, LIPC, MMACHC, MYO3A, MYOC, NOTCH3, NPR2; 91-100: OPA3, PCDH15, PDE11A, PDE2A, PEX1, POLR1C, POSTN, PRPF8, RAPGEF5, RELN; 101-110: SAMHD1, SARS2, SBDS, SCAF4, SHANK3, SLC12A3, SLC14A1, SLC22A5, SLC25A38, SLC26A8; 111-120: SLC34A2, SLC5A5, SPAG9, SPG20, SPINK1, SPTLC2, TALDO1, TAT, TGM1, TMEM67, TPMT; 121-129: TTN, TTN-AS1, TUBB1, UHRF1BP1L, VPS13B, VPS54, WRN, WWP1