Table 2 Diagnostic performances of aPL antibodies for arterial thrombosis
Fisher’s exact test | ROC curve analysis (Youden index) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameters | All, n | Pos., n | Neg., n | Sn | Sp | PPV | NPV | Accuracy | LR + | LR − | OR (95% CI) | Cut-off | All, n | Pos., n | Neg., n | Sn | Sp | Accuracy | AUC | Youden’s index | Optimal point |
LA test | 368 | 84 | 284 | 0.444 | 0.809 | 0.286 | 0.894 | 0.755 | 2.326 | 0.687 | 3.37 (1.75–6.45) | 1.2 | − | − | − | − | − | − | − | − | − |
aCL IgG [EIA] | 304 | 75 | 229 | 0.353 | 0.775 | 0.240 | 0.856 | 0.704 | 1.567 | 0.835 | 1.87 (0.92–3.72) | 10 | 304 | 51 | 253 | 0.373 | 0.787 | 0.717 | 0.583 | 0.159 | 12.0 |
aCL IgG [CIA] | 342 | 38 | 304 | 0.220 | 0.908 | 0.289 | 0.872 | 0.807 | 2.379 | 0.859 | 2.75 (1.14–6.32) | 20 | 342 | 50 | 292 | 0.360 | 0.825 | 0.757 | 0.587 | 0.185 | 10.7 |
aCL IgM [CIA] | 341 | 18 | 323 | 0.080 | 0.952 | 0.222 | 0.858 | 0.824 | 1.663 | 0.966 | 1.71 (0.39–5.79) | 20 | 341 | 50 | 291 | 0.620 | 0.533 | 0.546 | 0.542 | 0.153 | 2.30 |
aCLβ2GPI IgG [EIA] | 378 | 35 | 343 | 0.200 | 0.928 | 0.343 | 0.860 | 0.812 | 2.765 | 0.862 | 3.19 (1.35–7.22) | 3.5 | 378 | 60 | 318 | 0.350 | 0.846 | 0.767 | 0.584 | 0.196 | 1.30 |
aβ2GPI IgG [CIA] | 343 | 54 | 289 | 0.320 | 0.870 | 0.296 | 0.882 | 0.790 | 2.467 | 0.781 | 3.14 (1.47–6.53) | 20 | 343 | 50 | 293 | 0.826 | 0.400 | 0.764 | 0.602 | 0.226 | 14.0 |
aβ2GPI IgM [CIA] | 343 | 18 | 325 | 0.100 | 0.956 | 0.278 | 0.862 | 0.831 | 2.254 | 0.942 | 2.38 (0.63–7.57) | 20 | 343 | 50 | 293 | 0.911 | 0.160 | 0.802 | 0.510 | 0.071 | 7.10 |
anti-β2GPI/HLA-DR antibody | 704 | 193 | 511 | 0.442 | 0.746 | 0.176 | 0.916 | 0.713 | 1.741 | 0.748 | 2.32 (1.39 − 3.88) | 73.3 | 704 | 77 | 627 | 0.338 | 0.914 | 0.851 | 0.601 | 0.252 | 172.359 |