Fig. 2

Immunocyte were significantly increased in the liver and kidney of female TNF-Tg mice. A Representative images of immune cells in the liver of 3.5- to 5.5- month-old female TNF-Tg mice (scale bar, 200 μm). B–D Quantification of the number of immune cells including CD45R positive B cells (B, statistics: ***p = 0.0002; *p = 0.0103), CD3 positive T cells (C, statistics: **p = 0.0011; ***p = 0.0004; *p = 0.0136), and F4/80 iNOS double positive macrophages (D, statistics: ***p = 0.0006; *p = 0.0262; *p = 0.0355) in the liver of TNF-Tg mice were significantly increased compared to their matched WT littermates. E Representative images of immune cells in the kidney of 3.5- to 5.5-month-old female TNF-Tg mice (scale bar, 200 μm). F–H Quantification of the number of immune cells including CD45R positive B cells (F, statistics: ****p < 0.0001; ***p = 0.0008; ****p < 0.0001), CD3 positive T cells (G, statistics: ****p < 0.0001; **p = 0.005; ****p < 0.0001), and F4/80 iNOS double positive macrophage (H, statistics: ***p = 0.0004; ***p = 0.0001; **p = 0.0021) in the kidney of TNF-Tg mice were significantly increased compared to their matched WT littermates