Fig. 4

Systemic inflammation and liver damage were worsened in TNF-Tg mice. A–B Hepatic impairment was measured using blood, ALT (A, statistics: *p = 0.0108) and AST (B, statistics: **p = 0.0045) were significantly elevated in mice at 3.5 months of age. C–D There were no significant difference in TBILC (C) and DBILC (D) in the serum of the mice. E–F Creatinine (E, statistics: *p = 0.0201) at 5.5 months of age and urea nitrogen (F, statistics: **p = 0.0011) at 4.5 months of age were significantly elevated in TNF-Tg mice. G–H DPP-IV (G, statistics: **p = 0.0060) was significantly elevated in TNF-Tg mice at 5.5 months of age, and CES1 (H, statistics: **p = 0.0061) was significantly increased in mice at 4.5 months of age