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Table 2 Association of radiographic and symptomatic knee osteoarthritis with the risks of falls, recurrent falls, and fractures

From: Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis

Outcomes

Odds ratio (95% CI)

No. of participants (studies)

Certainty of the evidence (GRADE)

Comments

Falls

 SOA

1.08 (0.90 to 1.30)

9635 (4 studies)

Low (inconsistency and publication bias)

SOA may have no effect for increasing risk of falls

 ROA

1.28 (1.03 to 1.59)

3927 (4 studies)

Moderate (publication bias)

ROA may have a very small effect for increasing risk of falls

Recurrent falls

 SOA

1.55 (1.10 to 2.18)

2535 (1 study)

Moderate (imprecision)

SOA may have a small effect for increasing risk of recurrent falls

 ROA

1.39 (0.97 to 1.97)

998 (2 studies)

Low (imprecision and publication bias)

ROA may have very small or no effect for increasing risk of recurrent falls

Fractures

 SOA

0.87 (0.69 to 1.09)

912553 (7 studies)

Very low (risk of bias, inconsistency and publication bias)

SOA may have no effect for reducing risk of fractures

 ROA

1.23 (0.99 to 1.53)

4678 (3 studies)

Low (risk of bias and publication bias)

ROA may have no effect for reducing risk of fractures

  1. Risk of bias: The case group definition for Cumming et.al [43] is based on self-report, with selection bias and no response rate not stated. Case group definition for Arden et.al [14] is based on self-report, with selection bias and control group selected from hospital. Inconsistency: downgraded because the proportion of variance in the effect estimates caused by true heterogeneity rather than chance is important (I2 > 50%); Publication bias: funnel plot indicates a potential publication bias. Imprecision: only 1 study was available, and the wide CI may influence clinical decision
  2. CI confidence interval, GRADE Grading of Recommendations, Assessment, Development, and Evaluation, ROA radiographic osteoarthritis, SOA symptomatic osteoarthritis