Fig. 3
From: Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Inflammation in RA-affected joints. The pathogenesis of RA reflects the complex interactions between various cell groups in the synovium, mediated by direct contact between cells and various types of secreted or exfoliated molecules. mTOR signaling controls the recruitment and activation of innate, acquired immune cells and FLSs during RA, thus producing numerous chemokines, pro-inflammatory cytokines, and cathepsin to degrade the extracellular matrix and cartilage, further contributing to the early characteristics of synovitis