Fig. 3

Effects of CBX4 wild-type and mutants on SASP secretion by primary human OA chondrocytes. Comparison of SASP secretion, including IL-1β, IL-6, IL-8, TNF-α, MMP-1, MMP-3, and MMP-9, by primary human OA chondrocytes transduced with CBX4 wild-type (WT) or mutants. Repeated measures with Dunnett’s post hoc test were performed to compare WT and mutant CBX4. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001