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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus

Fig. 3

TLR7 or TLR9 stimulation is sufficient to induce PLD4 + B cells in healthy donors. A, B PBMCs from HDs were cultured in vitro with stimulants. A shows representative plots in one donor. In B, the ratios of induced PLD4 + B cells were represented by dots in the boxplots and compared between the stimulants. C Naive B cells isolated from three HDs were cultured with or without TLR9 ligand for 2 days, after which PLD4 mRNA expressions were measured by RT-qPCR. *P < 0.05, ***P < 0.01, ***P < 0.005, by Mann–Whitney U test in B and by the Wilcoxon signed-rank test in C

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Arthritis Research & Therapy

ISSN: 1478-6362

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