Interleukin-37: associations of plasma levels and genetic variants in gout

Andres Cerezo, Lucie; Navrátilová, Adéla; Hulejová, Hana; Pavlíková, Markéta; Závada, Jakub; Pavelka, Karel; Šenolt, Ladislav; Stiburkova, Blanka

doi:10.1186/s13075-023-03188-3

Arthritis Research & Therapy

Table 2 Number and frequency of detected variant alleles and levels of IL-37 in control subjects (N = 50), asymptomatic hyperuricemic (N = 74), intercritical gout (N = 200), acute gouty flare (N = 18), and chronic tophaceous gout (N = 30) cohorts

From: Interleukin-37: associations of plasma levels and genetic variants in gout

	IL-37 [pg/ml]	rs2708959	rs2723170	rs2708958	rs2723169	rs2466448	rs3811045	rs3811046	rs3811047	rs3811048	rs2708943	rs2723183	rs2708944	rs2723187	rs2708947	rs27231927
	Median (IQR)	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF	n MAF
European population (NCBI)		0.050	0.080	0.081	0.079	0.079	0.705	0.705	0.703	0.704	0.081	0.082	0.079	0.081	0.082	0.082
Control subjects (N = 50/50^a)	90.4 (49.9–122.5)	8	8	8	8	8	67	67	67	67	8	8	8	10	7	7
Control subjects (N = 50/50^a)	90.4 (49.9–122.5)	0.080	0.080	0.080	0.080	0.080	0.670	0.670	0.670	0.670	0.080	0.080	0.080	0.100	0.070	0.070
Asymptomatic hyperuricemic (N = 111/146^a)	158.9 (68.8–318.1)	8	8	8	8	8	109	109	109	109	10	10	9	8	8	8
Asymptomatic hyperuricemic (N = 111/146^a)	158.9 (68.8–318.1)	0.054	0.054	0.054	0.054	0.054	0.736	0.736	0.736	0.736	0.068	0.068	0.061	0.054	0.054	0.054
Intercritical gout (N = 182/206^a)	154.0 (76.3–270.8)	34	34	34	34	36	285	284	284	284	33	34	34	40	40	40
Intercritical gout (N = 182/206^a)	154.0 (76.3–270.8)	0.085	0.085	0.085	0.085	0.090	0.713	0.710	0.710	0.710	0.083	0.085	0.085	0.100	0.100	0.100
Chronic tophaceous gout (N = 20/30^a)	149.1 (83.7–188.5)	6	6	6	6	6	25	25	25	25	4	3	4	4	3	3
Chronic tophaceous gout (N = 20/30^a)	149.1 (83.7–188.5)	0.139	0.139	0.139	0.139	0.139	0.639	0.639	0.639	0.639	0.083	0.056	0.083	0.083	0.083	0.083
Acute gouty flare (N = 25/20^a)	168.5 (80.3–336.2)	5	5	5	5	5	34	34	34	34	2^b	2^b	2^b	3	3	3
Acute gouty flare (N = 25/20^a)	168.5 (80.3–336.2)	0.083	0.083	0.083	0.083	0.083	0.567	0.567	0.567	0.567	0.034	0.034	0.034	0.050	0.050	0.050

The cases where binomial test (compared to the European population MAF) p-value < 0.05 are in bold
IQR interquartile range, MAF minor allelic frequency, n number of alleles found
^aNumber of individuals with measured IL-37 levels/genotyped
^bFor rs2708943, rs2723183, and rs2708944, only 29 out of 30 individuals with acute gouty flare were genotyped

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