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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model

Fig. 6

Calpain inhibition halts Calpain-ACSL4 crosstalk and progressive fibrosis. A Schematic illustration of the treatment schedule. B, C Western blots of calpain 1 and calpain 2 in murine skin tissue from each group. D Calpain activity in murine skin tissue from each group. E H&E and Masson’s staining representative images of murine skin and lung tissue, data are summarized in graphs (n = 8). F, G Western blots of fibrosis markers in murine skin tissue from each group. H Relative mRNA levels of ACSL4 from each group. I, J Relative mRNA levels of M1 and M2 markers from each group. (Data are presented as Mean ± SD *p < 0.05, **p < 0.01, ***p < 0.001, * stands for control versus BLM group; #p < 0.05, ##p < 0.01, ###p < 0.001, #stands for BLM group versus BLM + PD150606-treated group)

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Arthritis Research & Therapy

ISSN: 1478-6362

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