Skip to main content

Table 2 Therapies applied at inclusion in the registry and at 4-year follow-up

From: Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome

 

At baseline

N = 400

After 4 years

N = 81 (all patients)

 

Any medication

387 (96.8%)

59 (72.8%)

p < 0.001

NSAIDs

344 (86%)

32 (39.5%)

p < 0.001

Systemic glucocorticoids, total

46 (11.5%)

3 (3.7%)

p = 0.003

 < 0.2 mg per kg BW

21 (5.3)

2 (2.5%)

p = 0.285

  ≥ 0.2 mg per kg BW

33 (8.3%)

2 (2.5%)

p = 0.068

Bisphosphonates

34 (8.5%)

3 (3.7%)

p = 0.140

DMARDs, totala

56 (16.4%)

21 (28.4%)

p = 0.008

csDMARDs

43 (12.6%)

13 (17.6%)

p = 0.129

 Methotrexate

30 (8.8%)

10 (13.5%)

p = 0.21

 Sulfasalazine

13 (3.8%)

3 (4.1%)

p = 0.836

bDMARD

21 (6.1%)

9 (12.2%)

p = 0.003

 Etanercept

10 (2.9%)

3 (4.1%)

p = 0.542

 Adalimumab

11 (3.2%)

6 (8.1%)

p = 0.05

  1. NSAIDs non-steroidal anti-rheumatic drugs, csDMARDs conventional synthetic disease-modifying anti-rheumatic drugs, bDMARDs biological DMARDs, BW body weight
  2. aInformation on DMARD therapy was available for 341 patients at baseline and 74 patients at 4-year follow-up, respectively