Fig. 4
From: Bruton’s tyrosine kinase is a possible therapeutic target in microscopic polyangiitis
Effects of tirabrutinib on MPA model rats. MPA model rats were given drug-free feed (n = 6) or tirabrutinib-containing feed (0.0037% or 0.012%) from day 0 (preadministration; n = 8 per group) or day 28 (postadministration; n = 8 per group). Hematuria (a) and proteinuria (b) were determined using urine samples collected on day 40 with a dipstick. All rats were euthanized on day 42 for histological evaluation, including glomerular lesion rate (c), tubular erythrocyte casts in the renal cortex (d), and pulmonary hemorrhagic foci (e). *p < 0.05; **p < 0.01; ***p < 0.005