Fig. 5
From: Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse
IA injection of recombinant Prok2 (rProk2) exacerbates post-traumatic OA cartilage destruction. A, B Sham- or DMM-operated mice were IA injected with BSA or rProk2 (10 μg/10 μ1/joint) once a week for 3 weeks (n=8 mice per group). Representative safranin-O staining images of joint sections at 6 weeks after surgery (A). Quantification of OARSI grade and osteophyte maturity at 6 weeks after surgery (B). Values are presented as median ± interquartile range (IQR) and significance was evaluated by Mann-Whitney U test. Scale bar: 50 μm