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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in rheumatoid arthritis development

Fig. 2

Identification of differential metabolites in plasma metabolic profile between NORA and CRA patients. A, B OPLA-DA analysis showed 29 differential metabolites between NORA and CRA in anionic and cationic patterns, respectively. C The bubble diagram showed a significant enrichment of differential metabolites between NORA and CRA in the glycerophospholipid metabolism and phenylalanine metabolism pathways, including 1-Palmitoyl-sn-glycero-3-phosphocholine, S-lysoPC, glycerophosphocholine, trans-cinnamate, L-Phenylalanine, and alpha-N-Phenylacetyl-L-glutamine. D–G Scatter plots demonstrated the relative abundance of 4 differential metabolites on glycerophospholipid metabolism and phenylalanine metabolism pathways between controls, NORA, and CRA. H Correlation heatmap showed the interrelationship between 6 differential metabolites and clinical characteristics. (S-lysoPC: 1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine; D-duration: disease duration)

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Arthritis Research & Therapy

ISSN: 1478-6362

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