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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in rheumatoid arthritis development

Fig. 5

Differences in gene expression profile and enrichment analysis between NORA and CRA groups. A GSEA (Gene Set Enrichment Analysis) enrichment analysis demonstrated that glycerophospholipid metabolism was significantly enriched in the control compared to NORA group. B GSEA enrichment analysis demonstrated a significant enrichment of citrate cycle (TCA) cycle in CRA compared to control. C Volcano plot showed differentially expressed genes between NORA and control, with 11 upregulated and 185 downregulated genes. D Volcano plot showed 211 differentially expressed genes between CRA and control, with 48 upregulated and 163 under-regulated genes. E Volcano plot showed 40 differentially expressed genes between NORA and CRA, with 10 were upregulated and 30 were downregulated. F, G Bubble plots illustrated the results of KEGG and GO enrichment analysis for 40 differentially expressed genes, respectively. H, I The bar graphs demonstrated the expression of ACHE and DGKI genes in the glycerophospholipid metabolism pathway

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Arthritis Research & Therapy

ISSN: 1478-6362

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