Fig. 1

Serum αCGRP is elevated in primary OA and knee but not hip joints of aged αCGRP-deficient mice are protected from cartilage degradation. A αCGRP serum concentrations and B body weight of indicated groups. C OARSI histopathological grading scores of knee and D hip joints of indicated groups. E Representative histological images of MB- and SO-stained sections of knee and F hip joints of indicated groups. Red dotted boxes indicate cartilage damage. Scale bars = 500 µm. Given values are median ± minimum and maximum. MB, methylene blue; SO, safranin O