Fig. 3

QTL mapping of median OA phenotype scores. Total joint OA measured in the entire cohort (A), an expanded view of chromosome 19, highlighting the genome-wide significant peak and associated genes (B). Total joint OA measured in the 8–12-month younger onset cohort (C), an expanded view of chromosome 17, highlighting the genome-wide significant peak and associated genes (D). Red lines indicate a threshold for genome-wide significance, and yellow lines indicate a genome-wide suggestive threshold. Below is a zoomed-in view of the chromosome containing the peak, the founder coefficient demonstrates the founder contributions to the locus and the genes implicated at the locus