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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: 4,8-Dicarboxyl-8,9-iridoid-1-glycoside inhibits apoptosis in human osteoarthritis chondrocytes via enhanced c-MYC-mediated cholesterol metabolism in vitro

Fig. 3

BIG treatment resulted in dysregulated gene levels and interacting signalling in human chondrocytes in OA. A Volcano map representing the altered expression levels of the 248 genes caused by BIG treatment. B Cytoscape of the top 20 hub genes, and BIG promoted the upregulation of MYC expression. C KEGG pathway analysis revealed differentially expressed genes enriched in cell cycle pathways. D Differential gene hierarchical clustering analysis between the control and BIG-treated groups was performed, and the results are displayed in a heatmap (n = 3, P < 0.05). Red indicates upregulated genes, and blue indicates downregulated genes

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Arthritis Research & Therapy

ISSN: 1478-6362

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