Table 1 Clinical characteristics of 90 patients at baseline

Clinical characteristics

 Number, n (%)

90 (100)

35 (39)

20 (22)

23 (26)

12 (13)

 Female, n (%)

57 (63)

25 (71)

18 (90)

7 (30)

7 (58)

0.0004^*

 Age, median (25th–75th)

63 (58–68)

63 (58–69)

59 (45–66)

65 (61–67)

63 (60–68)

0.0933

 Symptoms to diagnosis interval, months, median (25th–75th)

2 (1–6)

2 (1–12)

5 (1–12)

1 (1–3)

3 (1–4)

0.1194

Symptoms, n (%)

 Fever

25 (28)

1 (3)

2 (10)

20 (87)

2 (17)

 < 0.0001^*

 Weight loss

3 (3)

2 (6)

0 (0)

0 (0)

1 (8)

0.3871

 Rash

1 (1)

1 (3)

0 (0)

0 (0)

0 (0)

0.6619

 Arthritis

9 (10)

3 (9)

4 (20)

2 (9)

0 (0)

0.2984

 Myalgia

4 (4)

0 (0)

1 (5)

3 (13)

0 (0)

0.102

 Renal impairment at the onset

44 (49)

28 (80)

4 (20)

5 (22)

7 (58)

 < 0.0001^*

 Repaid progression

30 (33)

10 (29)

2 (10)

7 (30)

11 (92)

 < 0.0001^*

 Dialysis at diagnosis

12 (13)

1 (3)

0 (0)

1 (4)

10 (83)

 < 0.0001^*

 Cardiovascular symptoms

6 (7)

4 (11)

0 (0)

0 (0)

2 (17)

0.0989

 Digestive symptoms

1 (1)

1 (3)

0 (0)

0 (0)

0 (0)

0.6619

 Nervous symptoms

4 (4)

1 (3)

0 (0)

3 (13)

0 (0)

0.1271

 ENT involvement

5 (6)

2 (6)

0 (0)

3 (13)

0 (0)

0.2268

Renal biopsy, n (%)

90 (100)

 Focal

11 (12)

3 (9)

3 (15)

5 (22)

0 (0)

0.2415

 Mixed

31 (34)

7 (20)

13 (65)

11 (48)

0 (0)

0.0002^*

 Crescent

28 (31)

17 (49)

1 (5)

3 (13)

7 (58)

0.0003^*

 Sclerotic

20 (22)

8 (23)

3 (15)

4 (17)

5 (42)

0.3147

 Pulmonary involvement, n (%)

61 (67)

24 (69)

3 (15)

23 (100)

11 (92)

 Bronchiectasis

16 (18)

4 (11)

1 (5)

9 (39)

2 (17)

0.0156^*

 UIP or NSIP

42 (47)

19 (54)

2 (10)

14 (61)

7 (58)

0.0027^*

 Alveolar hemorrhage

2 (2)

0 (0)

0 (0)

0 (0)

2 (17)

0.004^*

Laboratory results, median (25th–75th)

 MPO-ANCA titers

5 (3–6)

5 (2–6)

4 (3–5)

5 (4–7)

4 (3–7)

0.1734

 BVAS

16 (12–18)

16 (14–16)

12 (10–13)

18 (16–19)

16 (13–20)

 < 0.0001^*

 Cr, μM

197 (121–349)

243 (184–308)

103 (82–163)

127 (109–277)

588 (490–966)

 < 0.0001^*

 eGFR

25 (12–50)

21 (15–26)

54 (29–77)

50 (16–61)

7 (5–9)

 < 0.0001^*

 Albumin, g/L

34 (30–36)

33 (30–38)

35 (33–38)

29 (27–35)

35 (29–36)

0.0364^*

 CRP, mg/L

18 (5–45)

21 (9–36)

3 (1–18)

102 (17–130)

12 (4–35)

 < 0.0001^*

 24 h urine protein, g/L

1.5 (0.8–2.7)

1.5 (0.9–2.4)

1.9 (0.8–3.2)

1.0 (0.8–1.5)

3.1 (2.6–3.5)

0.0008^*