Fig. 4

Gene expression of inflammatory and catabolic genes in chondrocytes. A In vitro model of IL1β stimulation: chondrocytes were treated with IL1β (1 ng/ml) for 24 h and then co-treated with pExo (100 µg/ml, N = 3 donors) or IL1-RA (1 µg/ml) for another 24 h before gene expression analysis by qPCR. B Expression levels of each gene were presented as mean ± 95% CI (vs IL1β treatment condition, t-test, *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.0001)