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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes

Fig. 2

Bulk RNA sequencing results. A The breakdown of D.E. genes between non-degenerated and degenerated CEP samples is depicted by a volcano plot. Positive F.C. indicates upregulation in degenerated samples, whereas negative F.C. indicates upregulation in non-degenerated samples. Thresholds for upregulation were set at |F.C.| ≥ 1.5 and significance was set at q < 0.05. Boxed numbers indicate number of significantly D.E. genes in each compartment of plot. B The results of the literature review are summarized by a Venn diagram showing the number of genes previously studied in the CEP, the IVD, or cartilage. C Breakdown of the genes previously studied in each tissue of interest. Purple-highlighted genes were previously studied in all three tissues and green-highlighted genes were previously studied in the IVD and cartilage only. F.C., fold change; D.E., differentially expressed

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Arthritis Research & Therapy

ISSN: 1478-6362

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