Fig. 2

FBP1 restores the metabolic disorders of chondrocytes and delays its aging in OA. Mouse primary chondrocytes were stimulated with IL-1β for 24 h and then treated with or without granules that could overexpress FBP1. A Quantitative PCR analysis of FBP1, SOX9, COL2A1, ACAN, MMP13, and ColX in chondrocytes. n = 5 per time point. *p < 0.05, **p < 0.01, ***p < 0.001, NS = not significant. One-way analysis of variance (ANOVA) was performed. B The SA-βGal staining and PAS staining of chondrocytes. Scale bars = 50 μm