Fig. 3

The overexpressing of FBP1 can suppress the degeneration of cartilage and delay the progression of OA. A Safranin O/fast green staining(first row), PAS staining (second row) images of knee cartilage from control group, destabilization of medial meniscus (DMM) group, and DMM with lentivirus group mice. Scale bars = 50 μm. B,C IHC staining of FBP1, SOX9, MMP13, P21, and P16 positive cells in articular cartilage of control group, DMM group, and DMM with lentivirus group mice. Scale bars = 50 μm. D–I Quantitative analysis of the OARSI scale and FBP1-positive, SOX9-positive, MMP13-positive, P21-positive, and P16-positive chondrocytes in mice. n = 5 per group. *p < 0.05, **p < 0.01, ***p < 0.001, NS = not significant. One-way analysis of variance (ANOVA) was performed