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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)

Fig. 6

A model of gluconeogenesis disorder with decrease of gluconeogenesis key enzyme FBP1 and leading to impaired polysaccharide synthesis, cartilage destruction, and other effects during osteoarthritis. OA causes gluconeogenesis disorders, resulting in a decrease in FBP1, impaired the synthesis of glycogen, glycosaminoglycans, and other polysaccharide substances, and leads to a decrease in the expression of CRB3, aggravating the aging and degeneration of cartilage

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Arthritis Research & Therapy

ISSN: 1478-6362

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