Fig. 5

Joint remobilization ameliorates OA lesions caused by short-term immobilization in mice. A 3D reconstruction from μCT scans of knee joints from control, immobilization for 2 weeks, remobilization after 2 weeks of immobilization. Scale bar, 1.0 mm. B–D The BV, BV/TV, and Tb.Th of osteophytes on both sides of femoral condyle were analyzed by μCT. E Representative images of SO/FG staining images in knee joints of different groups. Green arrowheads show synovial hyperplasia. Scale bar: 50 mm. F and G Synovitis score (F), OARSI score (G) based on staining results in (E). H Results of von Frey test. N = 6 biologically independent replicates per group. Results were expressed as mean ± standard deviation (sd). *P < 0.05, **P < 0.01. IB, immobilization; RB, remobilization