Fig. 1
From: Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis
WFR alleviates arthritis in CIA rats. Rats were administered on the 7th day after their first immunization, and arthritis scores were performed on the 35th days. A total of 40 μg/kg, 48 μg/kg, and 56 μg/kg of WFR had good effects on reducing arthritis score, which were determined as the experimental dose (A). WFR could significantly reduce paw swelling (B and C), reduce the arthritis score of CIA rats (D), increase the threshold of paw pain withdrawal (E), and restore the body weight of CIA rats (F). HE staining showed that WFR alleviated synovial hyperplasia and pannus formation in CIA rats (G). Masson staining showed that WFR could reduce bone tissue damage in CIA rats (H). C, D, E, F *CIA group vs normal, #CIA+WFR vs CIA group, n = 10. *p < 0.05