Fig. 5

Exo-srIκB exhibits the ability to suppress arthritis and reduce radiographic scores in CIA mouse model. A The upper panel shows the study protocol schematic. Arthritis scores were evaluated according to the clinical severity in each group, with five mice per group. Two-way analysis of variance (ANOVA) was performed to determine statistical significance for the clinical score. B In the upper panel, a representative tissue stain of the ankle joint at the end of the experiment is displayed. The lower panel presents the analysis of histological scores, including synovial hyperplasia, cartilage destruction, pannus formation, and bone erosion. C A representative microCT scan was shown. Radiographic scores were evaluated and analyzed for each group. Mann–Whitney U-test or Kruskal–Wallis test with Dunn’s multiple comparisons was performed to determine statistical significance for histologic and radiographic scores. Values are the mean ± SEM. Symbols represent the individual sample. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001