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Table 3 Group administration method and dose for RA rats

From: Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis

Group

Administration method

Drugs

Dose

Control group

IP

PBS (pH 7.5)

2 ml/time

RA model group

IP

PBS (pH 7.5)

2 ml/time

Methotrexate (MTX)

IP

MTX

2.5 mg/kg

(Zn-Adenine)@Ab

IAI

(Zn-Adenine)@Ab

100 µg/ml

(Zn-Adenine)@Ab + RA

IAI

(Zn-Adenine)@Ab

100 µg/ml

(Zn-Adenine)@Ab@lncRNA LEF1-AS1 + RA

IAI

(Zn-Adenine)@Ab@lncRNA LEF1-AS1

100 µg/ml

  1. IAI Intra-articular injection, IP Intraperitoneal injection