Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout

Qi, Han; Sun, Mingshu; Terkeltaub, Robert; Xue, Xiaomei; Li, Xinde; Cui, Lingling; He, Yuwei; Yan, Fei; Sun, Ruixia; Chen, Ying; Jia, Zhaotong; Cheng, Xiaoyu; Ma, Lidan; Liu, Tian; Dalbeth, Nicola; Li, Changgui

doi:10.1186/s13075-023-03228-y

Table 2 Baseline clinical variables associated with the SU target achievement

From: Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout

Indicators	Univariable logistic regression model			Multivariate logistic regression model
Indicators	OR	95% CI	P-value	OR	95% CI	P-value
All participants
Age, per year	1.02	(1.01, 1.04)	< 0.001	1.02	(1.00, 1.04)	0.086
Disease duration, per year	0.99	(0.96, 1.02)	0.584	0.97	(0.93, 1.00)	0.123
BMI, per kg/m²	0.95	(0.91, 1.00)	0.044	0.98	(0.93, 1.04)	0.524
Serum urate, per mg/dL	0.66	(0.57, 0.76)	< 0.001	0.74	(0.62, 0.89)	0.001
Blood glucose, per mmol/L	1.00	(0.81, 1.24)	1.000
eGFR, per ml/min/1.73 m²	0.97	(0.99, 1.00)	0.972
TG/HDL-C, per unit	0.65	(0.47, 0.91)	0.014	0.77	(0.52, 1.16)	0.217
Hypertension	1.00	(0.71, 1.4)	0.987
Fatty liver disease	1.06	(0.68, 1.64)	0.806
Combined type hyperuricemia	0.60	(0.41, 0.88)	0.008	0.64	(0.41, 0.99)	0.048
Renal overload subtype
Age, per year	1.05	(0.99, 1.10)	0.070	1.05	(0.99, 1.12)	0.107
Disease duration, per year	1.02	(0.93, 1.11)	0.665	1.00	(0.89, 1.11)	0.937
BMI, per kg/m²	0.95	(0.81, 1.13)	0.560	0.99	(0.80, 1.21)	0.908
Serum urate, per mg/dL	0.65	(0.39, 1.08)	0.096	0.73	(0.38, 1.41)	0.731
Blood glucose, per mmol/L	0.74	(0.43, 1.27)	0.272
eGFR, per ml/min/1.73 m²	1.00	(0.98, 1.04)	0.717
TG/HDL-C, per unit	0.93	(0.33, 2.65)	0.892
Hypertension	0.75	(0.28, 2.01)	0.562
Fatty liver disease	0.64	(0.16, 2.64)	0.537
Renal underexcretion subtype
Age, per year	1.02	(1.01, 1.04)	0.008	1.02	(0.99, 1.04)	0.248
Disease duration, per year	0.99	(0.96, 1.03)	0.666	0.97	(0.92, 1.03)	0.306
BMI, per kg/m²	0.99	(0.94, 1.05)	0.761	1.02	(0.96, 1.09)	0.515
Serum urate, per mg/dL	0.61	(0.51, 0.74)	< 0.001	0.65	(0.52, 0.81)	< 0.001
Blood glucose, per mmol/L	1.08	(0.82, 1.44)	0.583
eGFR, per ml/min/1.73 m²	1.00	(0.99, 1.01)	0.714
TG/HDL-C, per unit	0.65	(0.41, 1.02)	0.058	0.87	(0.51, 1.50)	0.622
Hypertension	1.26	(0.81, 1.98)	0.310
Fatty liver disease	0.93	(0.51, 1.72)	0.822
Combined subtype
Age, per year	1.01	(0.99, 1.05)	0.349	1.01	(0.97, 1.05)	0.629
Disease duration, per year	0.93	(0.85, 1.02)	0.117	0.91	(0.83, 1.79)	0.316
BMI, per kg/m²	0.89	(0.81, 0.99)	0.024	0.86	(0.76, 0.98)	0.018
Serum urate, per mg/dL	0.84	(0.64, 1.11)	0.216	1.22	(0.83, 1.79)	0.316
Blood glucose, per mmol/L	0.92	(0.60, 1.43)	0.719
eGFR, per ml/min/1.73 m²	1.00	(0.98, 1.02)	0.938
TG/HDL-C, per unit	0.68	(0.42, 1.30)	0.142	0.42	(0.18, 0.96)	0.039
Hypertension	0.59	(0.30, 1.19)	0.141	0.60	(0.25, 1.43)	0.246
Fatty liver disease	1.82	(0.87, 3.79)	.0211

BMI body mass index, eGFR estimated glomerular filtration rate, TG/HDL-C TG, triglyceride (mmol/L)/total high-density lipoprotein-cholesterol (mmol/L)

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