Fig. 1
From: In vivo study of newly developed albumin-conjugated urate oxidase for gout treatment
Comparative single dose PK profiles of PAT101, pegloticase, and rasburicase in BALB/c mice. PAT101, pegloticase, and rasburicase were injected to female BALB/c mice (n = 5 or 6). The injected test substances have the same molar concentration of uricase. The blood samples were collected at different time points: 0.25, 2, 4, and 8 hr for rasburicase, and 0.25, 2, 4, 8, 12, 24, 36, and 48 hr for pegloticase and PAT101. The calculated plasma uricase activity (mU/mL) in the log scale was plotted against time (hr) to examine the PK profiles. The values of PK parameters, half-life, and AUC are shown as mean ± SD