Fig. 4

Efficacy of PAT101 and pegloticase on pathological kidneys in Uox KO mice. A Macroscopic evaluation (upper panel) and H&E staining results (lower panel) of Uox KO mouse kidney tissues untreated or treated with either allopurinol, PAT101, or pegloticase. Tubular damage with dilated tubules is indicated by black arrows. B The histological inflammatory score was evaluated by one-way analysis of variance (ANOVA) statistical analysis containing tubular necrosis, loss of brush border, tubular dilatation, and cellular infiltration. The scoring was evaluated following the score 0: none, score 1: < 10%, score 2: 10–25%, score 3: 25–50%, score 4: 50–74%, score 5: > 75%), P value (ns: not significant, **: < 0.01). C Kapan-Meier survival analysis in four Uox KO groups without or with 3 different treatments such as allopurinol, PAT101, or pegloticase. D Analysis of uric acid concentration in Uox KO mice in four Uox KO groups without or with three different treatments such as allopurinol, PAT101, or pegloticase. The residual plasma uric acid was measured by the uric acid assay kits (Abnova, Taipei Taiwan). ns: not significant, **: < 0.01, ***: < 0.001