Fig. 5

The immunogenic responses of CD4⁺T/CD8⁺T cell to PAT101 or rasburicase. A, B Increase in the positive population of CD4⁺T-cell (A) and CD8⁺T cell (B) proliferative response (BrdU uptake) to PPD, PAT101, or rasburicase. C, D Stimulation index (SI) of CD4⁺T-cell (C) and CD8⁺T cell (D) to PAT101, rasburicase, and PPD were plotted. The blue dotted line indicates that the SI value is 2, and cases with SI ≥ 2 were considered positive. Purified protein derivative (PPD) was used as a positive control. Data is presented as mean ± SD