Table 1 The information of test substances, dosage, and administration interval by groups
From: In vivo study of newly developed albumin-conjugated urate oxidase for gout treatment
Group | # of mice | Test substance | Route of administration | Dosage (mg/kg) | Interval |
|---|---|---|---|---|---|
G1 | 5 | KO | - | - | - |
G2 | 5 | KO + allopurinol | Allopurinol (oral) | 25 | Allopurinol (once daily) |
G3 | 5 | KO + allopurinol + PAT101 | Allopurinol (oral) + PAT101 (I.P.) | Allopurinol (25) + PAT101 (6) | Allopurinol (once daily) + PAT101 (once weekly) |
G4 | 5 | KO + allopurinol + pegloticase | Allopurinol (oral) + pegloticase (I.P.) | Allopurinol (25) + pegloticase (2) | Allopurinol (once daily) + Pegloticase (once weekly) |