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Table 2 MR estimation of genetic reliability between SLE and PBC

From: Causal relationship between systemic lupus erythematosus and primary liver cirrhosis based on two-sample bidirectional Mendelian randomization and transcriptome overlap analysis

Exposure

Outcome

MR methods

SNPs (n)

OR

95% CI

P-value

SLE

PBC

MR Egger

16

1.073

0.816–1.412

0.6212

Weighted median

16

1.390

1.265–1.528

7.4353E − 12

Inverse variance weighted

16

1.308

1.131–1.513

0.0003

Simple mode

16

1.435

1.231–1.673

0.0003

Weighted mode

16

1.408

1.218–1.626

0.0003

PBC

SLE

MR Egger

22

1.103

0.763–1.596

0.6079

Weighted median

22

1.271

1.161–1.392

2.3155E − 07

Inverse variance weighted

22

1.407

1.199–1.652

2.9132E − 05

Simple mode

22

1.363

1.174–1.582

0.0006

Weighted mode

22

1.247

1.101–1.412

0.0022