Table 4 MR estimation of genetic reliability between SOCS3 and SLE/PBC
Exposure | Outcome | MR methods | SNPs (n) | OR | 95% CI | P-value |
|---|---|---|---|---|---|---|
SOCS3 | SLE | MR Egger | 62 | 0.937 | 0.843–1.041 | 0.2289 |
Weighted median | 62 | 0.975 | 0.883–1.075 | 0.6062 | ||
Inverse variance weighted | 62 | 0.992 | 0.936–1.051 | 0.7866 | ||
Simple mode | 62 | 0.907 | 0.741–1.111 | 0.3505 | ||
Weighted mode | 62 | 0.963 | 0.870–1.066 | 0.4701 | ||
SOCS3 | PBC | MR Egger | 4 | 1.761 | 0.731–4.242 | 0.3346 |
Weighted median | 4 | 1.345 | 0.962–1.882 | 0.0829 | ||
Inverse variance weighted | 4 | 1.387 | 1.049–1.835 | 0.0218 | ||
Simple mode | 4 | 1.282 | 0.844–1.948 | 0.3286 | ||
Weighted mode | 4 | 1.291 | 0.798–2.090 | 0.3741 |