Fig. 5
From: Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis
Transcriptomic analysis of the replication set. A Transcriptomic association study between responders vs. non-responders (meta-analysis of three datasets). Genes related to the OXPHOS pathway are color-coded(red: upregulated in non-responders, blue: downregulated in non-responders). B Results of cell type enrichment analysis. C Enrichment analysis of genes contributing to monocyte enrichment. D The OXPHOS scores in the GSE68215 data set. The P-value calculated by the Mann–Whitney U test is shown. E, F The OXPHOS scores in immune cells in peripheral blood (E) and in synovium tissue (F) in patients with RA. CD4, CD4 + T cell; CD8, CD8 + T cell; NK, NK cell; B, B cell; Mono, monocyte