Fig. 1

The MAPK signaling cascade is involved in the processes in FLSs treated with IL-1β. A Differentially expressed mRNAs in FLSs in response to IL-1β are illustrated as a heat map. B Volcano map showing differentially expressed mRNAs. C-D Gene ontology classification. E KEGG pathway classification. F Bubble map of KEGG enrichment analysis (Total). G Bubble map of KEGG enrichment analysis (Up) and correlational heatmap of different samples and MAP kinase activity and bone resorption-related markers in different samples