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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

Fig. 4

ADAM8 blockade suppresses FLS migration and invasion by inhibiting MMPs. A qRT-PCR analysis of the mRNA expression levels of ADAM8. B ADAM8 transfection efficiency was detected by fluorescence assay. C Immunofluorescence staining of ADAM8. D, G Wound healing assays and quantitative analysis of the migration ability of FLSs. E, H Transwell assays and quantitative analysis of the migration ability of FLSs. F, I Transwell assays and quantitative analysis of the invasion ability of FLSs with different concentrations of IL-1β. J Western blot and quantitative analysis of MMP-1 and MMP-13. K qRT-PCR analysis of the mRNA expression levels of MMP-1 and MMP-13. Scale bar = 200 µm. *P < 0.05; **P < 0.01

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Arthritis Research & Therapy

ISSN: 1478-6362

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