Fig. 6

ADAM8 blockade prevent IL-1β-stimulated biological phenotypes specific of FLSs by targeting FSCN1. A The differentially expressed mRNAs in FLSs between IL-1β group and IL-1β + siADAM8 are illustrated as a heat map. B Gene ontology classification. C The heat map shows the detected differential genes associated with cell migration. D, G Wound healing and quantitative analysis of the migration ability of FLSs. E, H Transwell assays and quantitative analysis of the migration ability of FLSs. F, I Transwell assays and quantitative analysis of the invasion ability of FLSs with different concentrations of IL-1β. J qRT-PCR analysis of the mRNA expression levels of FSCN1, MMP-1, and MMP-13. Scale bar = 200 µm. *P < 0.05; **P < 0.01