Table 3 The 25 most relevant pathways sorted by p-value

Collagen degradation

10/69

0.005

2.11e-15

7.55e-14

24/34

0.002

Degradation of the extracellular matrix

12/148

0.01

2.22e-15

7.55e-14

77/105

0.007

Activation of matrix

Metalloproteinases

8/35

0.002

4.63e-14

1.02e-12

22/27

0.002

Extracellular matrix organization

12/328

0.022

2.37e-11

4.02e-10

115/319

0.022

Interleukin-4 and interleukin-13 signaling

6/211

0.014

1.59e-05

2.07e-04

1/47

0.003

Assembly of collagen fibrils and

other multimeric structures

4/67

0.004

1.59e-05

2.07e-05

7/26

0.002

Collagen formation

4/104

0.007

1.50e-04

0.001

29/77

0.005

RUNX2 regulates genes involved in

cell migration

2/14

9.23e-04

6.17e-04

0.005

2/7

4.93e-04

Transcriptional regulation of testis

differentiation

2/21

0.001

0.001

0.01

14/18

0.001

Extranuclear estrogen signaling

3/11

0.007

0.003

0.018

1/39

0.003

Defective B3GALTL causes PpS

2/39

0.003

0.005

0.025

1/1

7.41e-05

O-glycosylation of TSR domain containing proteins

2/41

0.003

0.005

0.025

2/2

1.41e-04

Signaling by interleukins

6/658

0.043

0.006

0.026

1/505

0.036

Transcriptional regulation by RUNX2

3/147

0.01

0.006

0.026

3/84

0.006

EPH-ephrin-mediated repulsion of cells

2/55

0.004

0.009

0.036

1/9

6.34e-04

Diseases associated with O-glycosylation of proteins

2/78

0.005

0.017

0.069

1/9

6.34e-04

Zinc influx into cells by the SLC39 gene family

1/11

7.25e-04

0.028

0.084

1/6

4.23e-04

EPH-ephrin signaling

2/102

0.007

0.028

0.085

1/56

0.004

MAPK6/MAPK4 signaling

2/106

0.007

0.03

0.091

1/40

0.003

EGFR transactivation by gastrin

1/13

8.57e-04

0.033

0.092

2/6

4.23e-04

Zinc transporters

1/16

0.001

0.04

0.092

1/13

9.16e-04

O-linked glycosylation

2/133

0.009

0.046

0.092

2/27

0.002

Cytokine signaling in immune system

6/1036

0.068

0.047

0.095

1/740

0.052

Gastrin-CREB signaling pathway via

PKC and MAPK

1/24

0.002

0.06

0.12

2/9

6.34e-04