Table 2 Odds ratios for early response to treatment measured by fold change in C6M from baseline to week 4

Early non-responder

 Unadjusted

1.27

0.83

1.99

0.279

0.348

1.50

0.99

2.29

0.058

0.115

0.77

0.51

1.13

0.188

0.269

 Adjusted

1.28

0.83

2.03

0.267

0.334

1.52

0.99

2.36

0.059

0.117

0.76

0.50

1.13

0.182

0.261

DAS remission (< 2.6)

 Unadjusted

0.74

0.40

1.38

0.345

0.383

0.44

0.26

0.70

0.001

0.011

-

-

-

-

-

 Adjusted

0.77

0.43

1.38

0.390

0.433

0.41

0.24

0.66

< 0.001

0.005

-

-

-

-

-

DAS reduction (< 3.2)

 Unadjusted

0.67

0.41

1.05

0.085

0.141

0.59

0.39

0.86

0.008

0.038

-

-

-

-

-

 Adjusted

0.67

0.42

1.06

0.091

0.152

0.52

0.34

0.77

0.002

0.008

-

-

-

-

-

ACR50

 Unadjusted

0.62

0.40

0.95

0.031

0.076

0.64

0.43

0.93

0.021

0.071

0.86

0.46

1.63

0.635

0.635

 Adjusted

0.62

0.40

0.96

0.035

0.088

0.62

0.42

0.89

0.012

0.041

0.86

0.45

1.63

0.634

0.634