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Table 1 Clinical characteristics and laboratory features of the patients and healthy controls

From: Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis

Parameters

Healthy control (n = 10)

MDA5+non-RPILD (n = 10)

MDA5+RP-ILD (n = 10)

p-value

Female, n (%)

5 (50)

7 (70)

6 (60)

 > 0.99

Patient age, years, median (interquartile range)

41.00 (38.00,58.00)

44.50 (31.25, 54.00)

45.50 (42.75, 54.50)

0.65

General condition/inflammation

 ALT, U/L, median (interquartile range)

-

40.50 (20.80, 55.40)

40.75 (25.50, 108.58)

0.55

 AST, U/L, median (interquartile range)

-

54.20 (29.20, 68.90)

49.45 (35.38, 86.58)

0.55

 LDH, U/L, median (interquartile range)

-

279.5 (243.00, 357.25)

401.00 (353.00, 424.00)

0.019

 CK, U/L, median (interquartile range)

-

83.00 (42.75, 143.00)

87.50 (44.75, 111.75)

0.97

 ESR, mm/h, median (interquartile range)

-

33.00 (23.00, 49.00)

40.00 (32.00, 54.00)

0.6

 CRP, mg/L, median (interquartile range)

-

4.38 (3.05, 5.85)

9.76 (3.64, 20.05)

0.22

 SF, ng/mL, median (interquartile range)

-

382.60 (177.70, 1,008.10)

799.80 (94.75, 1,854.75)

 > 0.99

 Immunosuppressive therapy, n (%)

-

0 (0%)

3 (30%)

0.21

 Disease course, months, median (interquartile range)

-

3.00 (1.25, 4.00)

1.50 (1.00, 2.75)

0.38

Chronic disease status, n (%)

 Arthritis

0

3 (30)

2 (20)

0.63

 Diabetes

0

0 (0)

1 (10)

 > 0.99

 Kidney disease

0

0 (0)

0 (0)

-

 Cardiovascular disease

0

0 (0)

1 (10)

 > 0.99

Skin and muscular manifestations, n (%)

 Gottron

-

7 (70)

8 (80)

 > 0.99

 Heliotrope

-

5 (50)

5 (50)

 > 0.99

 Mechanic hands

-

4 (40)

4 (40)

 > 0.99

 Muscle weakness

-

2 (20)

5 (50)

0.35

 Myocardial involvement

-

1 (10)

0 (0)

0.63

 Periungual erythema

-

3 (30)

5 (50)

0.65

 Shawl signs

-

1 (10)

2 (20)

 > 0.99

 Skin erythema

-

6 (60)

3 (30)

0.37

 Skin ulcers

-

0 (0)

1 (10)

 > 0.99

 V syndrome

-

2 (20)

3 (30)

 > 0.99

Antibodies, n (%)

 MDA5

   

0.63

  + 

-

3 (30)

1 (10)

 

  +  + 

-

3 (30)

3 (30)

 

  +  +  + 

-

4 (40)

6 (60)

 

 ANA

-

4 (40)

4 (40)

 > 0.99

 Ro52

-

4 (40)

10 (100)

0.011

 Ro60

-

0 (0)

3 (30)

0.21

 PL12

-

1 (10)

0 (0)

 > 0.99

 Ku

-

1 (10)

0 (0)

 > 0.99

  1. Data are presented as median (interquartile range) or case number (percentage)
  2. Abbreviations: RP-ILD rapidly progressive interstitial lung disease, ALT alanine transaminase, AST aspartate transaminase, LDH lactate dehydrogenase, CK creatine kinase, ESR erythrocyte sedimentation rate, CRP C-reactive protein, SF serum ferritin, MDA5 anti-melanoma differentiation-associated gene five, ANA antinuclear antibody
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Arthritis Research & Therapy

ISSN: 1478-6362

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