Table 2 Sensitivity analysis of the associations between RA and CI
Exposures | Outcomes | Heterogeneity test | Pleiotropy test | MR-PRESSO | ||||
|---|---|---|---|---|---|---|---|---|
MR-Egger | IVW | MR-Egger intercept | Global test | |||||
Q | pval | Q | pval | Intercept | P | P | ||
Sensitivity analysis in the discovery samples | ||||||||
 RA (Ishigaki et al.) | Cognitive performance | 52.06 | 2.18E−01 | 52.19 | 2.46E−01 | − 2.84E−04 | 7.36E−01 | 2.56E−01 |
 RA (Ishigaki et al.) | Cognitive function | 27.61 | 9.75E−01 | 27.66 | 9.80E−01 | − 6.41E−04 | 8.32E−01 | 9.75E−01 |
Sensitivity analysis in replication samples | ||||||||
 RA (Ha et al.) | Cognitive performance | 62.69 | 2.82E−01 | 62.99 | 3.04E−01 | 4.50E−04 | 6.03E−01 | 3.30E−01 |
 RA (Ha et al.) | Cognitive function | 51.32 | 7.80E−01 | 51.64 | 7.98E−01 | 1.20E−03 | 5.73E−01 | 8.11E−01 |
 RA (Eyre et al.) | Cognitive performance | 8.38 | 3.97E−01 | 8.42 | 4.92E−01 | − 3.11E−04 | 8.44E−01 | 6.23E−01 |
 RA (Eyre et al.) | Cognitive function | 6.03 | 9.14E−01 | 6.68 | 9.18E−01 | − 3.56E−03 | 4.36E−01 | 9.46E−01 |