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Table 1 Descriptive characteristics of included RA patients with T2D

From: The effects of suppressing inflammation by tofacitinib may simultaneously improve glycaemic parameters and inflammatory markers in rheumatoid arthritis patients with comorbid type 2 diabetes: a proof-of-concept, open, prospective, clinical study

Clinical characteristics

40 RA patients with T2D

Demographics

 Age, years, mean ± sd

63.4 ± 9.9

 Female sex, %

68.9%

 Smoking habit, %

41.9%

 BMI, mean ± sd

28.2 ± 7.5

RA features

 RF and/or ACPA, %

69.8%

 Radiographic erosions, %

55.8%

 Extra-articular disease, %

25.6%

 Disease duration, years, %

7.1 ± 5.3

 Disease duration ≥ 5 years, %

63.8%

 Disease duration ≤ 1 years, %

12.2%

 DAS28-CRP, mean ± sd

4.1 ± 1.1

 SDAI, mean ± sd

18.0 ± 8.3

 ESR, mm/h mean ± sd

30.0 ± 15.0

 CRP, mg/dl, mean ± sd

0.5 ± 0.4

 Tender joints, mean ± sd

8.0 ± 5.0

 Swollen joints, mean ± sd

4.1 ± 2.3

 Patient Global Assessment, mean ± sd

5.9 ± 2.2

 VAS pain, mean ± sd

6.2 ± 3.6

 Evaluator Global Assessment, mean ± sd

5.7 ± 2.5

 HAQ, mean ± sd

1.25 ± 1

Comorbidity feature

 T2D, %

100.0%

 HbA1c %, mean ± sd

6.5 ± 3.9

 HOMA2-IR, mean ± sd

1.8 ± 1.2

 HOMA2-β, mean ± sd

72.3 ± 53.5

 FPG, mg/dL, mean ± sd

136.4 ± 45.7

 Total Cholesterol, mg/dL, mean ± sd

192.3 ± 68.6

 Triglycerides, mg/dL, mean ± sd

146.6 ± 25.2

 High blood pressure, %

60.5%

 Obesity, %

27.9%

 Dyslipidaemia, %

18.6%

 Clinical atherosclerosis, %

4.2%

 Previous Herpes Zoster, %

0.0%

 Kidney disease, %

0.0%

 Liver disease, %

0.0%

Therapies

 GCs, %

34.9%

 GCs, mg/daily, mean ± sd

2.1 ± 1.6

 csDMARD(s), %

72.5%

 MTX, %

67.4%

 Oral antidiabetic drugs, %

88.8%

 Metformin, %

76.5%

 Insulin, %

11.2%

  1. Abbreviations: BMI Body Mass Index, RF Rheumatoid Factor, ACPA Anti Citrullinated Peptide Antibodies, DAS28 Disease Activity Score using 28 joints, CRP C Reactive Protein, SDAI Simplified Disease Activity Index, ESR Erythrocyte Sedimentation Rate, VAS Visual Analogue Scale, HAQ-DI Health Assessment Questionnaire Disability Index, T2D Type 2 Diabetes, HbA1c glycated haemoglobin, HOMA2-IR HOmeostasis Model Assessment of Insulin Resistance, HOMA2-β HOmeostasis Model Assessment of β-cells, FPG fasting values of glucose, GC Glucocorticoids, csDMARD conventional synthetic Disease Modifying Anti-Rheumatic Drug, MTX Methotrexate