Table 3 Prevalence of adverse pregnancy outcome in patients with lupus nephritis according to the tacrolimus exposure
| Â | Tacrolimus exposure in pregnant with lupus nephritis | Logistic regression model | ||||
|---|---|---|---|---|---|---|
Factor | (-) | ( +) | P value | OR | 95% CI | P value |
N | 17 | 15 | Â | Â | Â | Â |
Overall APO (%) | 9 (52.9) | 8 (53.3) | 1.00 | 1.00 | 0.25–4.08 | 0.98 |
Maternal APO (%) | 6 (35.3) | 7 (46.7) | 0.77 | 1.60 | 0.39–6.64 | 0.51 |
Neonatal APO (%) | 7 (41.2) | 5 (33.3) | 0.93 | 0.71 | 0.17–3.03 | 0.65 |
PROMISSE.APO (%) | 4 (23.5) | 2 (13.3) | 0.66 | 0.50 | 0.08–3.22 | 0.47 |
Flare during pregnancy (%) | 3 (17.6) | 2 (13.3) | 1.00 | 0.72 | 0.10–5.01 | 0.74 |
Flare after conception (%) | 1 (6.2) | 2 (15.4) | 0.57 | 2.73 | 0.22–34 | 0.44 |
Hypertensive Disorders of Pregnancy (%) | 4 (23.5) | 3 (20.0) | 1.00 | 0.81 | 0.15–4.4 | 0.81 |
Preeclampsia (%) | 3 (17.6) | 2 (13.3) | 1.00 | 0.72 | 0.10–5.01 | 0.74 |
Eclampsia (%) | 1 (5.9) | 0 (0.0) | 1.00 | NA | NA | NA |
HELLP syndrome (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
Gestational DM (%) | 2 (11.8) | 3 (20.0) | 0.65 | 1.87 | 0.27–13 | 0.53 |
Oligohydramnios (%) | 1 (5.9) | 1 (6.7) | 1.00 | 1.14 | 0.07–20 | 0.93 |
PROM (%) | 0 (0.0) | 1 (6.7) | 0.47 | NA | NA | NA |
Maternal death (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
Live birth | 16 (94.1) | 13 (86.7) | 0.91 | 0.41 | 0.03–5 | 0.48 |
Total duration of gestation (days) | 264.0 [259.0, 268.0] | 271.0 [262.0, 276.0] | 0.045 | NA | NA | NA |
Preterm birth (%) | 3 (18.8) | 1 (7.1) | 0.60 | 0.33 | 0.31–3.64 | 0.37 |
Spontaneous abortion (%) | 0 (0.0) | 0 ( 0.0) | NA | NA | NA | NA |
Missed abortion (%) | 0 (0.0) | 1 (6.7) | 0.47 | NA | NA | NA |
Iatrogenic abortion (%) | 1 (5.9) | 1 (6.7) | 1.00 | 1.14 | 0.07–20.0 | 0.93 |
Still birth (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
Planned C section (%) | 5 (31.2) | 2 (15.4) | 0.41 | 0.40 | 0.06–2.52 | 0.33 |
Emergency C section (%) | 4 (25.0) | 8 (61.5) | 0.07 | 4.80 | 0.98–23.5 | 0.05 |
Height at birth (cm) | 46.9 [45.2, 47.4] | 49.5 [46.5, 50.5] | 0.10 | NA | NA | NA |
Weight at birth (g) | 2627.5 [2438.0, 2770.3] | 2914.0 [2812.0, 3025.0] | 0.03 | NA | NA | NA |
Low birth weight (%) | 6 (37.5) | 2 (15.4) | 0.24 | 0.30 | 0.05–1.86 | 0.20 |
SGA (%) | 1 (6.2) | 2 (15.4) | 0.57 | 2.73 | 0.22–34 | 0.44 |
Apgar score (1Â min) | 8.0 [8.0, 8.0] | 8.0 [8.0, 8.0] | 0.77 | NA | NA | NA |
Apgar score (5Â min) | 9.0 [9.0, 9.0] | 9.0 [9.0, 9.0] | 0.88 | NA | NA | NA |
Major malformation (%) | 0 (0.0) | 1 (7.7) | 0.45 | NA | NA | NA |
Death of neonate (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |